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anti-BTLA (human), mAb (6F4)

AG-20B-0049
AdipoGen Life Sciences
ApplicationsFlow Cytometry, ELISA
Product group Antibodies
TargetBTLA
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-BTLA (human), mAb (6F4)
  • Delivery Days Customer
    10
  • Applications
    Flow Cytometry, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    6F4
  • Concentration
    1 mg/ml
  • Estimated Purity
    >95%
  • Gene ID151888
  • Target name
    BTLA
  • Target description
    B and T lymphocyte associated
  • Target synonyms
    B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA1; CD272
  • Host
    Rat
  • Isotype
    IgG1
  • Protein IDQ7Z6A9
  • Protein Name
    B- and T-lymphocyte attenuator
  • Scientific Description
    B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory function of HVEM. BTLA also interacts with HVEM in cis, forming a heterodimeric complex in naive T cells that inhibits HVEM-dependent signaling. The cis-interaction between HVEM and BTLA is the predominant form expressed on the surface of naive human and mouse T cells and may be important to limit trans-signaling by LIGHT, BTLA, and CD160 that are expressed in adjacent activated cells. - Monoclonal Antibody. Recognizes human BTLA. Isotype: Rat IgG1. Clone: 6F4. Applications: ELISA, FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol. B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203

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