Anti-CD11a [SPVL1]

Absolute Antibody

Anti-CD11a [SPVL1]

9

This antibody is specific for human CD11a. CD11a is a receptor for ICAM1, ICAM2, ICAM3, ICAM4, F11R, and the secreted form of ubiquitin-like protein ISG15. CD11a is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction

To prove that LFA-1 and Mo-1 have a similar backbone, immunoprecipitation was performed on human leukocytes using the mouse version of this antibody (Keizer et al, 1985; pmid:2933266). To characterize this antibody, immunoprecipitation was performed on JY cells using the mouse version of this antibody. Furthermore, a cytotoxic assay was performed on human CTL clones HG-38 (T3+, T4+) and HG-31 (T3+, T8) using this antibody. Finally, blood leukocytes, thymocytes, and several lymphoid cell lines were stained using this antibody (Spits et al, 1983; pmid:6332061). A proliferation assay was used on lymphocyte populations with the mouse version of this antibody to study autocrine proliferation in human helper T cell clones. The antibody only blocked proliferation stimulated by PBMC, but not by B-LCL (Pawelec et al, 1989; pmid:2521616).

Functional Assay, ImmunoFluorescence, ImmunoPrecipitation, Neutralisation/Blocking

Research Use Only

Monoclonal

SPVL1

ITGAL

integrin subunit alpha L

antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; CD11 antigen-like family member A; CD11A; integrin alpha-L; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; LFA-1; LFA-1 alpha; LFA1A; LFA-1A; lymphocyte function-associated antigen 1, alpha polypeptide

Human

IgG1

Integrin alpha-L

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203