anti-CD244 [2B4] (human), mAb (ANC2B4/3B12) (preservative free)

Ancell Corporation

anti-CD244 (human), mAb (ANC2B4/3B12) (preservative free)

7

Binds to a CD244 epitope that is distinct from the binding sites of clone ANC244.8 (ANC-239-020) and clone C1.7.

Flow Cytometry, ELISA

Research Use Only

Monoclonal

ANC2B4/3B12

>95%

Liquid

Mouse

IgG1

CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation. - Monoclonal Antibody. Binds to a CD244 epitope that is distinct from the binding sites of clone ANC244.8 (ANC-239-020) and clone C1.7. Isotype: Mouse IgG1kappa. Clone: ANC2B4/3B12. Applications: ELISA, FACS. Liquid. 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl. CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.

Human

2°C to 8°C

12352203