Immunohistochemical staining of formalin fixed and paraffin embedded human lung adenocarcinoma tissue section using anti-CK-7 rabbit monoclonal antibody (Clone RM416) at a 1:100 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human lung adenocarcinoma tissue section using anti-CK-7 rabbit monoclonal antibody (Clone RM416) at a 1:100 dilution.
anti-CD278 (human), Rabbit Monoclonal (RM417)
REV-31-1303-00
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-CD278 (human), Rabbit Monoclonal (RM417)
- Delivery Days Customer5
- Antibody SpecificityThis antibody reacts to human CD278.
- ApplicationsImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM417
- FormulationLiquid
- Gene ID29851
- Target nameICOS
- Target descriptioninducible T cell costimulator
- Target synonymsactivation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CVID1; inducible costimulator; inducible T-cell costimulator; inducible T-cell co-stimulator
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y6W8
- Protein NameInducible T-cell costimulator
- Scientific DescriptionCD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. - Recombinant Antibody. This antibody reacts to human CD278. Applications: IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CD278 (ICOS; CRP1; CD28-related protein-1) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.
- ReactivityHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203