Anti-CD30 [Ki-3]

Absolute Antibody

Anti-CD30 [Ki-3]

7

The antibody binds to CD30.

The antibody binds specifically to CD30, a cell membrane protein which belongs to the tumour necrosis factor receptor family. Incubation of CD30 positive L540 cells with Ki-3 antibody weakly enhances release of soluble CD30 (in contrast to Ki-4, Ab00475). CD30 is expressed on activated lymphocytes, and binding by its ligands TRAF2 and TRAF5 results in the activation of NF-kappaB, thereby regulating gene expression. CD30 is also associated with Hodgkin Lymphoma, and its expression acts as a tumour marker. Targeting the CD30 antigen with specific monoclonal antibodies is a possible therapy for Hodgkins lymphoma.

Flow Cytometry, ImmunoFluorescence, ELISA, ImmunoHistoChemistry, Other Application

ELISA; FC; IHC; IF; activate

Research Use Only

Monoclonal

Ki-3

TNFRSF8

TNF receptor superfamily member 8

CD30; CD30L receptor; cytokine receptor CD30; D1S166E; Ki-1; Ki-1 antigen; lymphocyte activation antigen CD30; tumor necrosis factor receptor superfamily member 8

Human

Tumor necrosis factor receptor superfamily member 8

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

Human CD30.

-20°C,2°C to 8°C

12352203