Anti-CD33 [SGN-33 (Lintuzumab)]

Absolute Antibody

Anti-CD33 [SGN-33 (Lintuzumab)]

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This antibody is specific for human CD33, which is restricted to cells of the myelomonocytic lineage. CD33 but does not appear in abundance on normal cells, but is over-expressed in AML and other myeloproliferative diseases.

In vitro, this antibody is capable of mediating ADCC against AML cells (Caron, 1998). Though shown to be safe in phase III trials, the use of this antibody in combination with induction chemotherapy did not result in a statistically significant improvement in response rate or survival in patients with refractory/relapsed AML (Feldman, 2005).

Functional Assay

Research Use Only

Monoclonal

SGN-33 (Lintuzumab)

CD33

CD33 molecule

CD33 antigen (gp67); CD33 molecule transcript; gp67; myeloid cell surface antigen CD33; p67; sialic acid-binding Ig-like lectin 3; SIGLEC3; SIGLEC-3

Human

IgG1

Myeloid cell surface antigen CD33

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Human

-20°C,2°C to 8°C

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