Anti-CD39 [I-392]

Absolute Antibody

Anti-CD39 [I-392]

7

This antibody recognizes and binds human CD39. NTPDase 1 (ectonucleoside triphosphate diphosphohydrolase, also known as CD39/ENTPD1 or vascular CD39, functions together with another enzyme, CD73 (ecto-5- nucleosidase), to hydrolyze extracellular adenosine

The binding characterization of this antibody for CD39 expressed on Ramos cells was done using flow cytometry (WO2018065552). The binding of this antibody to various recombinant human CD39 isoforms was detected using ELISA. This antibody bound only vascular CD39, without any binding to CD39-L1, CD39-L2, CD39-L3 or CD39-L4. This antibody did not induce or increase CD39 down regulation. It was reported that this antibody is very potent at blocking CD39 enzymatic activity and is capable of neutralizing ATPase activity (US20190153113).

Flow Cytometry, ELISA, Neutralisation/Blocking

FC; ELISA; neutralize

Research Use Only

Monoclonal

I-392

ENTPD1

ectonucleoside triphosphate diphosphohydrolase 1

ATPDase; CD39; CD39 antigen; ecto-apyrase; ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; ecto-ATPDase 1; ectonucleoside triphosphate diphosphohydrolase 1; lymphoid cell activation antigen; NTPDase-1; SPG64

Human

IgG1

Ectonucleoside triphosphate diphosphohydrolase 1

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.

Human

Human

-20°C,2°C to 8°C

12352203