Anti-CD68 [FA-11]

Absolute Antibody

Anti-CD68 [FA-11]

9

This antibody is specific for murine CD68, known also as macrosialin (MS). CD68 is a 110 kDa, heavily O- and N- glycosylated type I integral membrane protein belonging to the sialomucin family and is closely related to the lysosomal/endosomal-associated m

When it was first generated, this antibody was used in binding assays, immunoprecipitation (IP) and immunofluorescence (IF) to study the differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes (Smith et al., 1987). Subsequently, this antibody has been utilised in numerous FACS, IP, IHC, ICC/IF, WB applications, for instance, to delineate the roles of mouse and human CD68 as macrophage receptors for oxidised low density lipoprotein (Ramprasad et al., 1996), to indicate that mice unresponsive to granulocyte-macrophage colony-stimulating factor (GM-CSF) are unexpectedly resistant to cutaneous Leishmania major infection (Scott et al., 2000), to characterise the macrophage subsets harbouring Leishmania donovani in spleens of infected BALB/c mice (Lang et al., 2000), and to examine the role of Foxp3(+) Tregs in Alzheimers disease (Baruch et al., 2015).

Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry

Research Use Only

Monoclonal

FA-11

Cd68

CD68 antigen

gp11; gp110; La; Lamp4; ma; macrosialin; Sca; Scard1

Rabbit

IgG

Macrosialin

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203