anti-CST3 / Cystatin C antibody

Arigo Biolaboratories

anti-CST3 / Cystatin C antibody

23

ELISA

Research Use Only

Monoclonal

Unconjugated

CST3

cystatin C

ARMD11; bA218C14.4 (cystatin C); cystatin 3; cystatin-C; epididymis secretory protein Li 2; gamma-trace; HEL-S-2; neuroendocrine basic polypeptide; post-gamma-globulin

Mouse

IgG1

Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide), a protein encoded by the CST3 gene,is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition), such as Alzheimers disease. In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family.

Human

-20°C

12352203