Anti-EphA3 [KB004]

Absolute Antibody

Anti-EphA3 [KB004]

7

This antibody has been shown to have a wide therapeutic potential. Human version of this antibody was shown to be safe for treatment of patients with refractory hematologic malignancies (Swords et al, 2016; pmid:27736729). Further, it has been shown that this antibody was cytotoxic to LK63 cell lines (Charmsaz et al, 2017; pmid:27922598). Besides this, the antibody was also shown to reduce multiple myeloma angiogenesis (Caivano et al, 2017; pmid:28415715). Fianlly, this antibody has been observed to reduice lung fibrosis is mice (WO2018053032).

Functional Assay

therapeutic; functional assay

Research Use Only

Monoclonal

KB004

EPHA3

EPH receptor A3

EK4; EPH-like kinase 4; eph-like tyrosine kinase 1; ephrin type-A receptor 3; ETK; ETK1; HEK; HEK4; human embryo kinase 1; testicular tissue protein Li 64; TYRO4; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor ETK1

Mouse

IgG1

Ephrin type-A receptor 3

Human

This antibody was created by humanizing the IIIA4 antibody. The IIIA4 antibody was raised by immunizing mice with LK63 cells.

-20°C,2°C to 8°C

12352203