Anti-FCGRT Antibody

HUABIO

Anti-FCGRT Antibody

7

Western Blot

WB

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

FCGRT

Fc gamma receptor and transporter

FCRN, FcgammaRn, alpha-chain, IgG receptor FcRn large subunit p51, Fc fragment of IgG receptor and transporter, Fc fragment of IgG, receptor, transporter, alpha, FcRn alpha chain, IgG Fc fragment receptor transporter alpha chain, heavy chain of the major histocompatibility complex class I-like Fc receptor, immunoglobulin receptor, intestinal, heavy chain, major histocompatibility complex class I-like Fc receptor, neonatal Fc receptor, neonatal Fc-receptor for Ig, neonatal fragment crystallizable Fc receptor FcRn, transmembrane alpha chain of the neonatal receptor

Rabbit

IgG

IgG receptor FcRn large subunit p51

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk . IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation . In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB .

Human

Human

-20°C,2°C to 8°C

41116161