Anti-FcRn [h22-0015]

Absolute Antibody

Anti-FcRn [h22-0015]

9

The antibody was employed in blocking experiments with HEK293 cells that overexpress FcRn. The results showed that the antibody has a good effect of blocking the binding of IgG to FcRn at the cellular level (IC50: 11.4nM). The effect of the antibody was tested in human FcRn transgenic mice. The antibody was able to increase IgG catabolism in vivo by blocking FcRn binding (CN113484526).

Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

h22-0015

FCGRT

Fc gamma receptor and transporter

FCRN, FcgammaRn, alpha-chain, IgG receptor FcRn large subunit p51, Fc fragment of IgG receptor and transporter, Fc fragment of IgG, receptor, transporter, alpha, FcRn alpha chain, IgG Fc fragment receptor transporter alpha chain, heavy chain of the major histocompatibility complex class I-like Fc receptor, immunoglobulin receptor, intestinal, heavy chain, major histocompatibility complex class I-like Fc receptor, neonatal Fc receptor, neonatal Fc-receptor for Ig, neonatal fragment crystallizable Fc receptor FcRn, transmembrane alpha chain of the neonatal receptor

Rabbit

IgG

IgG receptor FcRn large subunit p51

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203