Anti-Fibronectin [L19 (Radretumab)]

Absolute Antibody

Anti-Fibronectin [L19 (Radretumab)]

9

This antibody is specific for human fibronectin; it binds an epitope within the ED-B domain.

The original version of this antibody (human scFv) was determined to bind human fibronectin at the ED-B domain with a Kd of 54 pM using SPR. Furthermore, the antibody forms a stable complex with the fluorescently labeled ED-B and exhibits a long half-life when complexed with it (Pini et al., 1998; PMID: 9705314). This antibody was used for ELISA on biotinylated ED-B. Furthermore, it was used for a radioimmunoassay conducted on mice with subcutaneously implanted murine F9 teratocarcinoma, and for immunohistochemistry and Immunofluorescence performed on the corneas of New Zealand white rabbits (US8097254). Various formats of this antibody were used in an ELISA on the ED-B domain of FN (Borsi et al, 2002; pmid:12353237). This antibody was used for immunohistochemistry on tissues from patients with HNSCC (Birchler et al., 2003; PMID: 12838025). A radiolabeled version of this antibody was used for SPECT/CT on patients with SCC (Birchler et al., 2007; PMID: 17418248).

ImmunoFluorescence, ELISA, ImmunoHistoChemistry, RadioImmunoAssay

Research Use Only

Monoclonal

L19 (Radretumab)

FN1

fibronectin 1

CIG; cold-insoluble globulin; ED-B; epididymis secretory sperm binding protein; fibronectin; FINC; FN; FNZ; GFND; GFND2; LETS; migration-stimulating factor; MSF; SMDCF

Fibronectin

Human

-20°C,2°C to 8°C

12352203