anti-FLIP, mAb (Dave-2)

AdipoGen Life Sciences

anti-FLIP, mAb (Dave-2)

10

ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

Dave-2

1 mg/ml

CFLAR

CASP8 and FADD like apoptosis regulator

CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, cFLIP, CASP8 and FADD-like apoptosis regulator, FADD-like antiapoptotic molecule 1, MACH-related inducer of toxicity, caspase homolog, caspase-eight-related protein, caspase-like apoptosis regulatory protein, caspase-related inducer of apoptosis, cellular FLICE-like inhibitory protein, inhibitor of FLICE, testis secretory sperm-binding protein Li 233m, usurpin beta

Rat

IgG2a

CASP8 and FADD-like apoptosis regulator

FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes. - Monoclonal Antibody. Recognizes an epitope (aa 1-200) present in both short (FLIPS) and long (FLIPL) splice variants of human and mouse FLIP. Isotype: Rat IgG2a. Clone: Dave-2. Applications: IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.

-20°C,2°C to 8°C

12352203