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Anti-Gelsolin [GsnVHH 13]

AB02737-23.159-BT
Absolute Antibody
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA
Product group Antibodies
TargetGSN
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-Gelsolin [GsnVHH 13]
  • Delivery Days Customer
    9
  • Application Supplier Note
    Gelsolin is a multifunctional actin-binding protein that controls cellular actin organization and migration. The original VHH version of this antibody binds calcium activated gelsolin with a Kd of ~10 nM. The specificity of the antibody towards gelsolin was confirmed with ELISA. GsnVHH 13 expressed as intrabodies immunoprecipitate endogenous gelsolin. His-tagged GsnVHH 13 can be used to identify gelsolin in a western blot assay. This antibody can trace gelsolin in membrane ruffles of EGF-stimulated MCF-7 cells and delay cellmigration without affecting F-actin severing/capping oractin nucleation activities by gelsolin as demonstrated by immunofluorescense staining. (PMID:20140750).
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GsnVHH 13
  • Gene ID2934
  • Target name
    GSN
  • Target description
    gelsolin
  • Target synonyms
    actin-depolymerizing factor; ADF; AGEL; brevin; epididymis secretory sperm binding protein; gelsolin
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP06396
  • Protein Name
    Gelsolin
  • Scientific Description
    This chimeric rabbit antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203

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