Anti-HMGB2 Antibody

HUABIO

Anti-HMGB2 Antibody

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

HMGB2

high mobility group box 2

HMG2, high mobility group protein B2, HMG-2, high mobility group protein 2, high-mobility group (nonhistone chromosomal) protein 2

Rabbit

IgG

High mobility group protein B2

High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFkappaB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161