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Anti-Hu CD152 APC

1A-785
EXBIO
ApplicationsFlow Cytometry
Product group Antibodies
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Overview

  • Supplier
    EXBIO
  • Product Name
    Anti-Hu CD152 APC
  • Delivery Days Customer
    7
  • Application Supplier Note
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 microl reagent / 100 microl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clone ID
    BNI3
  • Conjugate
    APC (Allophycocyanin)
  • Isotype
    IgG2a
  • Scientific Description
    CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

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