Immunohistochemical staining of human tissue using anti-IL-33 (human), mAb (IL33305B) (Prod. No. AG-20A-0041) at 1:100 dilution.A. Immunoperoxidase staining (cytoplasmic) of formalin-fixed, paraffin-embedded human heart (100x, brown colour).B.
Immunohistochemical staining of human tissue using anti-IL-33 (human), mAb (IL33305B) (Prod. No. AG-20A-0041) at 1:100 dilution.A. Immunoperoxidase staining (cytoplasmic) of formalin-fixed, paraffin-embedded human heart (100x, brown colour).B.
anti-IL-33 (human), mAb (IL33305B)
AG-20A-0041
ApplicationsImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman
TargetIL33
Overview
- SupplierAdipoGen Life Sciences
- Product Nameanti-IL-33 (human), mAb (IL33305B)
- Delivery Days Customer10
- Antibody SpecificityRecognizes human IL-33. Does not cross-react with mouse IL-33.
- ApplicationsImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDIL33305B
- Concentration1 mg/ml
- FormulationLiquid
- Gene ID90865
- Target nameIL33
- Target descriptioninterleukin 33
- Target synonymsC9orf26; DVS27; DVS27-related protein; IL1F11; interleukin-1 family member 11; interleukin-33; NFEHEV; NF-HEV; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules
- HostMouse
- IsotypeIgG2a
- Protein IDO95760
- Protein NameInterleukin-33
- Scientific DescriptionInterleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. - Monoclonal Antibody. Recognizes human IL-33. Does not cross-react with mouse IL-33. Isotype: Mouse IgG2akappa. Clone: IL33305B. Applications: ELISA, FUNC (Blocking), IHC, IP, WB. Liquid. 0.2microm-filtered solution in PBS, pH 7.4. Contains no preservatives. Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
- ReactivityHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203