Anti-IL12RB1 [148C09], Human IgG1-Fc Fusion,

Absolute Antibody

Anti-IL12RB1 [148C09], Human IgG1-Fc Fusion,

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The binding of the original version of this antibody (VHH) to IL12RB1 was characterized in an SPR (KD 3.3 nM), ELISA (IC50 3.7 and 1.5 nM for IL-12 and IL-23, respectively), and FACS (EC50 1.3 nM). In its bi-specific constructs with Ab04387 (Anti-CD4 [3F11]), it served a functional role (US20220242958).

Flow Cytometry, ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

148C09

IL12RB1

interleukin 12 receptor subunit beta 1

CD212; cluster of differentiation 212; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL12RB; IL-12R-BETA1; IMD30; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain; interleukin-12 receptor subunit beta-1

Human

IgG1

Interleukin-12 receptor subunit beta-1

This chimeric human antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203