anti-IL12RB1 antibody

Arigo Biolaboratories

anti-IL12RB1 antibody

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

IL12RB1

interleukin 12 receptor subunit beta 1

CD212, IL-12R-BETA1, IL12RB, IMD30, interleukin-12 receptor subunit beta-1, IL-12 receptor beta component, IL-12 receptor subunit beta-1, IL-12R subunit beta-1, cluster of differentiation 212, interleukin 12 receptor, beta 1, interleukin-12 receptor beta-1 chain

Rabbit

IgG

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

-20°C

12352203