anti-MAP3K8 antibody

Arigo Biolaboratories

anti-MAP3K8 antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

MAP3K8

mitogen-activated protein kinase kinase kinase 8

augmented in rheumatoid arthritis 2; AURA2; c-COT; COT; cot (cancer Osaka thyroid) oncogene; EST; ESTF; Ewing sarcoma transformant; MEKK8; mitogen-activated protein kinase kinase kinase 8; proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; TPL2; Tpl-2; tumor progression locus 2

Rabbit

IgG

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Human

-20°C

12352203