Western blot: NIH 3T3 cell lysates showing specific immunolabeling of the ~45kDa MEK 1/2 protein phosphorylated at Ser218 and Ser222. The cells were either serum starved (Control) or incubated in the presence of serum (Serum) stained with ARG52333 anti-MEK1/2 phospho (Ser218 / 222) antibody. Immunolabeling of an additional band at ~95kDa was also observed.
Western blot: NIH 3T3 cell lysates showing specific immunolabeling of the ~45kDa MEK 1/2 protein phosphorylated at Ser218 and Ser222. The cells were either serum starved (Control) or incubated in the presence of serum (Serum) stained with ARG52333 anti-MEK1/2 phospho (Ser218 / 222) antibody. Immunolabeling of an additional band at ~95kDa was also observed.
anti-MEK1/2 phospho (Ser218 / 222) antibody
ARG52333
ApplicationsWestern Blot
Product group Antibodies
ReactivityBovine, Canine, Chicken, Human, Primate, Rat, Xenopus, Zebra Fish
TargetMAP2K1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-MEK1/2 phospho (Ser218 / 222) antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID5604
- Target nameMAP2K1
- Target descriptionmitogen-activated protein kinase kinase 1
- Target synonymsCFC3; dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEK1; MEL; MKK1; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionMEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). This pathway also plays a key role in synaptic plasticity in the brain (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).
- ReactivityBovine, Canine, Chicken, Human, Primate, Rat, Xenopus, Zebra Fish
- Storage Instruction-20°C
- UNSPSC12352203