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anti-Nampt (Visfatin/PBEF) (human), pAb (NT)

AG-25A-0026
AdipoGen Life Sciences
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
TargetNAMPT
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-Nampt (Visfatin/PBEF) (human), pAb (NT)
  • Delivery Days Customer
    10
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Gene ID10135
  • Target name
    NAMPT
  • Target description
    nicotinamide phosphoribosyltransferase
  • Target synonyms
    1110035O14Rik; NAmPRTase; nicotinamide phosphoribosyltransferase; PBEF; PBEF1; pre-B cell-enhancing factor; pre-B-cell colony-enhancing factor 1; VF; VISFATIN
  • Host
    Rabbit
  • Protein IDP43490
  • Protein Name
    Nicotinamide phosphoribosyltransferase
  • Scientific Description
    Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity. - Polyclonal Antibody. Recognizes human Nampt. Weakly cross-reacts with mouse Nampt. Detects a band of ~54kDa by Western blot. Source: Rabbit. Applications: ELISA, IHC. Liquid. 0.2microm-filtered solution in PBS, pH 7.4. Contains no preservatives. Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203

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