Anti-NKG2A [Z199]

Absolute Antibody

Anti-NKG2A [Z199]

9

This antibody binds the human NKG2a. It can also recognize and bind the CD94/NKG2a heterodimer formed by the covalent association of CD94 with the NKG2a molecule. The CD94/NKG2a heterodimer acts as an inhibitory natural killer cell receptor and binds nonc

This antibody was reported to be a non-competitive antagonist of human CD94/NKG2A receptor expressed on lymphocytes, since it inhibited the function of CD94/NKG2A. Z199 can block the function of human CD94/NKG2A, and specifically induce killing of cells by CD94/NKG2A-restricted lymphocytes in a concentration-dependent fashion (US8796427). This antibody was used to study the covalent interactions between CD94 and NKG2A, which together form the inhibitory natural killer cell receptor (PMID: 9045931). This antibody was used to study the binding interactions of HLA-E (wild-type) tetramer to CD94/NKG2A or CD94/NKG2C expressing cells by flow cytometry (PMID: 14971033). This antibody was used to test the cytotoxic activity of NKL cells against tumor cells. NKL cells were tested for their ability to lyse the indicated targets in a 51Cr release assay, this antibody was found to enhance NK lysis (PMID: 21969815).

Flow Cytometry, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

Z199

KLRC1

killer cell lectin like receptor C1

CD159 antigen-like family member A; CD159A; C-lectin type II protein; killer cell lectin-like receptor subfamily C, member 1; natural killer cell lectin; natural killer group protein 2; NK cell receptor A; NKG2; NKG2-1/B activating NK receptor; NKG2A; NKG2-A/B type II integral membrane protein; NKG2-A/B-activating NK receptor; NKG2-A/NKG2-B type II integral membrane protein

Mouse

IgG2b

NKG2-A/NKG2-B type II integral membrane protein

Human

-20°C,2°C to 8°C

12352203