Anti-NKG2D [11B2D10]

Absolute Antibody

Anti-NKG2D [11B2D10]

7

This antibody recognizes and binds the extracellular epitope of NKG2D and blocks the interaction between ligand and receptor.

The NKG2D (Natural Killer Group 2 Member D) protein is an activating receptor that enables NK and CD8+ T cells to recognize and eliminate infected or transformed endogenous cells. However, incorrect regulation of this receptor on immune cells also appears to lead to the development of autoimmune diseases such as type I diabetes, celiac disease, and RA. This antibody positively reacts with NKG2D on CD8-positive T cells and to CD56-positive natural killer cells. The binding was confirmed by FACS analysis (Steigerwald, 2008).

Flow Cytometry, Neutralisation/Blocking

FC; blocking

Research Use Only

Monoclonal

11B2D10

KLRK1

killer cell lectin like receptor K1

CD314; D12S2489E; killer cell lectin-like receptor subfamily K, member 1; KLR; NK cell receptor D; NKG2D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor

Mouse

IgG1

NKG2-D type II integral membrane protein

Human

Human

The original antibody was generated by immunizing BALB/c mice with soluble NKG2-D fragments containing amino acids from 64-462 and 123-462.

-20°C,2°C to 8°C

12352203