Anti-Notch 4 [GLA-S4F18]

Absolute Antibody

Anti-Notch 4 [GLA-S4F18]

7

This antibody is capable of binding both human and mouse notch 4. Ths binding epitope of this antibody is located in the negative regulatory region or the NRR.

The original human IgG1, GLA-S4F18 antibody binds human and mouse notch 4 with an EC50 of 0.09 nM and 0.11 nM respectively as measured by direct ELISA. The binding of this antibody to surface expressed notch 4 was determined by flow cytometry. This antibody was reported to significantly delay tumor regrowth when administered in combination with carboplatin in an ovarian xenograft tumor model. When used in combination with cisplatin it delayed tumor regrowth in ovarian PDX models. It also resulted in reduction in cancer stem cells (CSC) present in tumors when treated with GLA-S4F18 alone or in combination with abraxane (WO2018039107).

ELISA

ELISA;

Research Use Only

Monoclonal

GLA-S4F18

NOTCH4

notch receptor 4

INT3; neurogenic locus notch homolog protein 4; notch 4; Notch homolog 4

Mouse

IgG2a

Neurogenic locus notch homolog protein 4

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

Human, mouse

The original antibody was isolated from a phage display library generated from a non immunized donor and panning against human and mouse Notch4-negative regulatory region or NRR antigens.

-20°C,2°C to 8°C

12352203