anti-PRMT1 antibody
ARG54089
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetPRMT1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-PRMT1 antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID3276
- Target namePRMT1
- Target descriptionprotein arginine methyltransferase 1
- Target synonymsANM1; HCP1; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HRMT1L2; interferon receptor 1-bound protein 4; IR1B4; protein arginine N-methyltransferase 1
- HostMouse
- IsotypeIgG2b
- Scientific DescriptionArginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1,histone H2,H3 and H4,PIAS1,HNRNPA1,HNRNPD,NFATC2IP,SUPT5H,TAF15 and EWS.Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a,respectively),a specific tag for epigenetic transcriptional activation.Together with dimethylated PIAS1,represses STAT1 transcriptional activity,in the late phase of interferon gamma (IFN-gamma) signaling.May be involved in the regulation of TAF15 transcriptional activity,act as an activator of estrogen receptor (ER)-mediated transactivation,play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation,by modulating p38 MAPK pathway.Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203