anti-RIG-I, mAb (Alme-1) (Biotin)

AdipoGen Life Sciences

anti-RIG-I, mAb (Alme-1) (Biotin)

10

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

Alme-1

0.5 mg/ml

Biotin

>95%

RIGI

RNA sensor RIG-I

DDX58, RIG-I, RIG1, RLR-1, SGMRT2, antiviral innate immune response receptor RIG-I, ATP-dependent RNA helicase DDX58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, DEAD box protein 58, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, DExD/H-box helicase 58, RNA helicase RIG-I, probable ATP-dependent RNA helicase DDX58, retinoic acid-inducible gene 1 protein, retinoic acid-inducible gene I protein

Mouse

IgG1

Probable ATP-dependent RNA helicase DDX58

Monoclonal Antibody. Recognizes human and mouse RIG-I. Isotype: Mouse IgG1. Clone: Alme-1. Applications: IHC, IP, WB. Liquid. In PBS containing 0.02% sodium azide. RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation. - RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

-20°C,2°C to 8°C

12352203