Anti-Sclerostin [AbD09097]
AB03705-23.0-BT
ApplicationsELISA, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman, Mouse
TargetSOST
Overview
- SupplierAbsolute Antibody
- Product NameAnti-Sclerostin [AbD09097]
- Delivery Days Customer9
- Antibody SpecificityThis antibody binds mouse sclerostin and cross reacts with human sclerostin and recognizes an epitope adjacent to sclerostins binding site for the Wnt co-receptor LRP6. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) doma
- Application Supplier NoteThe binding reactivity of this antibody for mouse sclerostin was tested using ELISA. This antibody binds mouse and human sclerostin with a binding affinity of Kd= 46nM and Kd=260 nM respectively. This antibody efficiently neutralizes sclerostins Wnt inhibitory activity. In vitro interaction analysis using sclerostin variants revealed that this neutralizing Fab binds to sclerostins flexible second loop, which has been shown to harbor the LRP5/6 binding motif (PMID: 27558933).
- ApplicationsELISA, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDAbD09097
- Gene ID50964
- Target nameSOST
- Target descriptionsclerostin
- Target synonymsCDD; DAND6; sclerostin; SOST1; VBCH
- HostRabbit
- IsotypeIgG
- Protein IDQ99P68
- Protein NameSclerostin
- ReactivityHuman, Mouse
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203