anti-ST2 (human), pAb (ATTO 647N)

AdipoGen Life Sciences

anti-ST2 (human), pAb (ATTO 647N)

10

Flow Cytometry, Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

Atto 647N

IL1RL1

interleukin 1 receptor like 1

DER4; FIT-1; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL33R; interleukin 1 receptor-related protein; interleukin-1 receptor-like 1; ST2; ST2L; ST2V; T1

Rabbit

Interleukin-1 receptor-like 1

Polyclonal Antibody. Recognizes endogenous ST2 by Flow Cytometry. Source: Rabbit. Applications: ELISA, FACS, WB. Liquid. In PBS containing 0.02% sodium azide. ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naive state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease. - ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naive state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.

2°C to 8°C

12352203