Anti-TIGIT [4D4]

Absolute Antibody

Anti-TIGIT [4D4]

9

4D4 specifically recognises TIGIT.

4D4 is an agonistic anti-TIGIT antibody, and addition of plate bound 4D4 to anti-CD3/anti-CD28 stimulated T cells was shown to inhibit their proliferation (Joller 2011). Further, 4D4 has been used in order to identify genes that are downstream of TIGIT signaling in Tregs, as TIGIT engagement might modulate the Treg phenotype in tumor tissue (Liu 2016).

Flow Cytometry, Other Application

Research Use Only

Monoclonal

4D4

Mouse

IgG1

T-cell immunoreceptor with Ig and ITIM domains

This chimeric mouse antibody was made using the variable domain sequences of the original Hamster format, for improved compatibility with existing reagents, assays and techniques.

Mouse

-20°C,2°C to 8°C

12352203