Anti-TIGIT [4D4]

Absolute Antibody

Anti-TIGIT [4D4]

9

4D4 is an agonistic anti-TIGIT antibody, and addition of plate bound 4D4 to anti-CD3/anti-CD28 stimulated T cells was shown to inhibit their proliferation (Joller 2011). Further, 4D4 has been used in order to identify genes that are downstream of TIGIT signaling in Tregs, as TIGIT engagement might modulate the Treg phenotype in tumor tissue (Liu 2016).

Flow Cytometry, Other Application

Research Use Only

Monoclonal

4D4

Mouse

T-cell immunoreceptor with Ig and ITIM domains

This is a bispecific anti-mouse antibody created by fusing anti-PDL-1 VHH domains to the C-terminus of the heavy chains) of the anti-mouse TIGIT antibody clone 4D4 in a mouse IgG1 D265 format. The mouse IgG1 D265 a format is an Fc-silenced format, preventing ADCC and CDC.

-20°C,2°C to 8°C

12352203