Anti-TIM-3 [mab15]

Absolute Antibody

Anti-TIM-3 [mab15]

9

This antibody can inhibit the interaction between TIM-3 and LILRB2 and can be used in the treatment of TIM-3 related disorders. The binding characterization of this antibody to human and mouse TIM-3 was done using ELISA and flow cytometry. Blocking of TIM-3:LILRB2 interactions by this antibody was evaluated in activated-macrophage and activated-DC assays. This antibody was able to initiate TNFalpha secretion in LPS activated macrophages. The stimulation of pro-inflammatory cytokines GM-CSF, IL-1alpha, IL-1beta, IL-6 and TNFalpha by this antibody was greater for macrophages from the LILRB2+ donor compared to the low LILRB2 donor

Functional Assay, Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

mab15

HAVCR2

hepatitis A virus cellular receptor 2

CD366, HAVcr-2, KIM-3, SPTCL, TIM3, TIMD-3, TIMD3, Tim-3, hepatitis A virus cellular receptor 2, T cell immunoglobulin mucin 3, T-cell immunoglobulin and mucin domain 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, kidney injury molecule-3

Human

IgG1

Hepatitis A virus cellular receptor 2

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human, Mouse

-20°C,2°C to 8°C

12352203