Anti-TIM-3 [mab15]

Absolute Antibody

Anti-TIM-3 [mab15]

7

This antibody binds human TIM-3 and capable of inhibiting the interaction of TIM-3 and LILRB2. It is reported that this antibody strongly binds CC loop and mildly to the DE loop of TIM-3. Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cel

This antibody can inhibit the interaction between TIM-3 and LILRB2 and can be used in the treatment of TIM-3 related disorders. The binding characterization of this antibody to human and mouse TIM-3 was done using ELISA and flow cytometry. Blocking of TIM-3:LILRB2 interactions by this antibody was evaluated in activated-macrophage and activated-DC assays. This antibody was able to initiate TNFalpha secretion in LPS activated macrophages. The stimulation of pro-inflammatory cytokines GM-CSF, IL-1alpha, IL-1beta, IL-6 and TNFalpha by this antibody was greater for macrophages from the LILRB2+ donor compared to the low LILRB2 donor

Functional Assay, Flow Cytometry, ELISA, Neutralisation/Blocking

inhibit; ELISA; FC; functional assay

Research Use Only

Monoclonal

mab15

HAVCR2

hepatitis A virus cellular receptor 2

CD366; HAVcr-2; hepatitis A virus cellular receptor 2; kidney injury molecule-3; KIM-3; SPTCL; T cell immunoglobulin mucin 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; Tim-3; TIMD3; TIMD-3

Rabbit

IgG

Hepatitis A virus cellular receptor 2

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human, Mouse

Human, mouse

The original antibody was generated by immunizing BALB/c mice or SJL mice with human and mouse TIM-3-Fc protein.

-20°C,2°C to 8°C

12352203