Anti-TLR7 [rE3]

Absolute Antibody

Anti-TLR7 [rE3]

7

This antibody binds human toll-like receptor 7 (TLR7). It also cross reacts with monkey TLR7. It is an endosomal receptor that plays a key role in innate and adaptive immunity. It also controls host immune response against pathogens through recognition of

This antibody was used in combination with another anti-TLR7 antibody called TLM3 to detect human TLR7 in a sandwich ELISA. LTM3 was used as used as a capturing antibody and biotinylated rE3 antibody (rE3-bio) was used a detecting antibody. This antibody can be used for the detection of human TLR7 in serum or plasma derived from human peripheral blood. The binding ability of this antibody for Ba/F3 cell line expressing human TLR7, mouse TLR7 and monkey TLR7 was checked using flow cytometry. This antibody can successfully detect human and monkey TLR7, but not mouse TLR7 in a flow cytometry. This antibody was also used in the detection of soluble human TLR7 in a sample using immunoprecipitation (US20210199667).

Flow Cytometry, ImmunoPrecipitation, ELISA

ELISA; FC; IP

Research Use Only

Monoclonal

rE3

TLR7

toll like receptor 7

IMD74; TLR7-like; toll-like receptor 7; toll-like receptor 7-like

Rabbit

IgG

Toll-like receptor 7

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format for improved compatibility with existing reagents assays and techniques.

Human, Monkey

Human, monkey

The original antibody was generated by immunizing wild-type Wister rat with Ba/F3 cell line expressing hTLR7-Flag-Hisx6/hUnc93B1-HAx2 mixed with a suitable adjuvant.

-20°C,2°C to 8°C

12352203