Anti-Topoisomerase II alpha Antibody

HUABIO

Anti-Topoisomerase II alpha Antibody

7

ImmunoFluorescence, Western Blot

WB,IF-Cell

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Top2a

topoisomerase (DNA) II alpha

Top-2, DNA topoisomerase 2-alpha, DNA Topoisomerase II alpha, DNA topoisomerase II, alpha isozyme

Rabbit

IgG

DNA topoisomerase 2-alpha

DNA topoisomerases I and II are nuclear enzymes; type II consists of two highly homologous isoforms: topoisomerase IIalpha and IIbeta. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Topoisomerases are very susceptible to various stresses. Acidic pH or oxidative stress can convert topoisomerases to DNA-breaking nucleases, causing genomic instability and cell death. DNA-damaging topoisomerase targeting drugs (e.g., etoposide) also convert topoisomerases to nucleases, with the enzyme usually trapped as an intermediate that is covalently bound to the 5+ end of the cleaved DNA strand(s).

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161