anti-ZAP70 (human), Rabbit Monoclonal (RM408)

RevMAb Biosciences

anti-ZAP70 (human), Rabbit Monoclonal (RM408)

10

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM408

ZAP70

zeta chain of T cell receptor associated protein kinase 70

70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; IMD48; SRK; STCD; STD; syk-related tyrosine kinase; tyrosine-protein kinase ZAP-70; TZK; ZAP-70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD

Rabbit

IgG

Tyrosine-protein kinase ZAP-70

Recombinant Antibody. This antibody reacts to human ZAP70. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. ZAP70 is a member of the Syk tyrosine kinase family and plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling. ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). In systemic lupus erythematosus, the Zap-70 receptor pathway is missing and Syk takes its place. - ZAP70 is a member of the Syk tyrosine kinase family and plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling. ZAP-70 in B cells is used as a prognostic marker in identifying different forms of chronic lymphocytic leukemia (CLL). In systemic lupus erythematosus, the Zap-70 receptor pathway is missing and Syk takes its place.

-20°C

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