APC antibody

GeneTex

APC antibody [ALi 12-28]

9

This antibody has been used routinely for Western blotting on colon cell line HCT116, SW480 and SW837 extracts.

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

1.2 mg/ml

Unconjugated

APC

APC regulator of WNT signaling pathway

adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli (APC); adenomatous polyposis coli protein; APC, WNT signaling pathway regulator; BTPS2; deleted in polyposis 2.5; DESMD; DP2; DP2.5; DP3; epididymis secretory sperm binding protein; GS; PPP1R46; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator

Mouse

IgG1

Adenomatous polyposis coli protein

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

-20°C or -80°C,2°C to 8°C

12352203