ASCL1 antibody
GTX129189
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Human, Rat
TargetASCL1
Overview
- SupplierGeneTex
- Product NameASCL1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.42 mg/ml
- ConjugateUnconjugated
- Gene ID429
- Target nameASCL1
- Target descriptionachaete-scute family bHLH transcription factor 1
- Target synonymsachaete scute protein; achaete-scute complex homolog 1; achaete-scute complex-like 1; achaete-scute homolog 1; ASH1; ASH-1; bHLHa46; class A basic helix-loop-helix protein 46; HASH1; MASH1
- HostRabbit
- IsotypeIgG
- Protein IDP50553
- Protein NameAchaete-scute homolog 1
- Scientific DescriptionThis gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq]
- ReactivityCanine, Human, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Dependence on the MUC1-C Oncoprotein in Classic, Variant, and Non-neuroendocrine Small Cell Lung Cancer.Read more
- MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas. Luan Z et al., 2022 Feb 11, CarcinogenesisRead more
- All-trans retinoic acid induces reprogramming of canine dedifferentiated cells into neuron-like cells. Nakano R et al., 2020, PLoS OneRead more
- MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Yasumizu Y et al., 2020 Jan 17, Nat CommunRead more