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ASCL1 antibody

GTX129189
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Human, Rat
TargetASCL1
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Overview

  • Supplier
    GeneTex
  • Product Name
    ASCL1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.42 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID429
  • Target name
    ASCL1
  • Target description
    achaete-scute family bHLH transcription factor 1
  • Target synonyms
    achaete scute protein; achaete-scute complex homolog 1; achaete-scute complex-like 1; achaete-scute homolog 1; ASH1; ASH-1; bHLHa46; class A basic helix-loop-helix protein 46; HASH1; MASH1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP50553
  • Protein Name
    Achaete-scute homolog 1
  • Scientific Description
    This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq]
  • Reactivity
    Canine, Human, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Dependence on the MUC1-C Oncoprotein in Classic, Variant, and Non-neuroendocrine Small Cell Lung Cancer.
    Read more
  • MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas. Luan Z et al., 2022 Feb 11, Carcinogenesis
    Read more
  • All-trans retinoic acid induces reprogramming of canine dedifferentiated cells into neuron-like cells. Nakano R et al., 2020, PLoS One
    Read more
  • MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer. Yasumizu Y et al., 2020 Jan 17, Nat Commun
    Read more