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WB analysis of K562 lysate using GTX89973 ATF4 antibody, C-term. Dilution : 0.3microg/ml Loading : 35microg protein in RIPA buffer
WB analysis of K562 lysate using GTX89973 ATF4 antibody, C-term. Dilution : 0.3microg/ml Loading : 35microg protein in RIPA buffer
WB analysis of K562 lysate using GTX89973 ATF4 antibody, C-term. Dilution : 0.3microg/ml Loading : 35microg protein in RIPA buffer

ATF4 antibody, C-term

GTX89973
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATF4
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATF4 antibody, C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 0.3-1microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.50 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID468
  • Target name
    ATF4
  • Target description
    activating transcription factor 4
  • Target synonyms
    CREB-2, CREB2, TAXREB67, TXREB, cyclic AMP-dependent transcription factor ATF-4, DNA-binding protein TAXREB67, cAMP response element-binding protein 2, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, cyclic AMP-responsive element-binding protein 2, tax-responsive enhancer element B67, tax-responsive enhancer element-binding protein 67
  • Host
    Goat
  • Isotype
    IgG
  • Protein IDP18848
  • Protein Name
    Cyclic AMP-dependent transcription factor ATF-4
  • Scientific Description
    This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Xie MX, Cao XY, Zeng WA, et al. ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. Nat Commun. 2021,12(1):1401. doi: 10.1038/s41467-021-21731-1
    Read this paper
  • Wu PS, Yen JH, Kou MC, et al. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. PLoS One. 2015,10(6):e0130599. doi: 10.1371/journal.pone.0130599
    Read this paper
  • Lin MH, Yen JH, Weng CY, et al. Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways. Toxicology. 2014,315:24-37. doi: 10.1016/j.tox.2013.11.007
    Read this paper
  • Weng CY, Chiou SY, Wang L, et al. Arsenic trioxide induces unfolded protein response in vascular endothelial cells. Arch Toxicol. 2014,88(2):213-26. doi: 10.1007/s00204-013-1101-x
    Read this paper