
WB analysis of K562 lysate using GTX89973 ATF4 antibody, C-term. Dilution : 0.3microg/ml Loading : 35microg protein in RIPA buffer
ATF4 antibody, C-term
GTX89973
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATF4
Overview
- SupplierGeneTex
- Product NameATF4 antibody, C-term
- Delivery Days Customer9
- Antibody SpecificityThis antibody is expected to recognize both reported isoforms (NP_001666.2; NP_877962.1).
- Application Supplier NoteWB: 0.3-1microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- Gene ID468
- Target nameATF4
- Target descriptionactivating transcription factor 4
- Target synonymscAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB2; CREB-2; cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; TAXREB67; tax-responsive enhancer element B67; tax-responsive enhancer element-binding protein 67; TXREB
- HostGoat
- IsotypeIgG
- Protein IDP18848
- Protein NameCyclic AMP-dependent transcription factor ATF-4
- Scientific DescriptionThis gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. Xie MX et al., 2021 Mar 3, Nat CommunRead more
- Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. Wu PS et al., 2015, PLoS OneRead more
- Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways. Lin MH et al., 2014 Jan 6, ToxicologyRead more
- Arsenic trioxide induces unfolded protein response in vascular endothelial cells. Weng CY et al., 2014 Feb, Arch ToxicolRead more