
WB analysis of K562 lysate using GTX89973 ATF4 antibody, C-term. Dilution : 0.3microg/ml Loading : 35microg protein in RIPA buffer
ATF4 antibody, C-term
GTX89973
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATF4
Overview
- SupplierGeneTex
- Product NameATF4 antibody, C-term
- Delivery Days Customer9
- Application Supplier NoteWB: 0.3-1microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- Gene ID468
- Target nameATF4
- Target descriptionactivating transcription factor 4
- Target synonymsCREB-2, CREB2, TAXREB67, TXREB, cyclic AMP-dependent transcription factor ATF-4, DNA-binding protein TAXREB67, cAMP response element-binding protein 2, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, cyclic AMP-responsive element-binding protein 2, tax-responsive enhancer element B67, tax-responsive enhancer element-binding protein 67
- HostGoat
- IsotypeIgG
- Protein IDP18848
- Protein NameCyclic AMP-dependent transcription factor ATF-4
- Scientific DescriptionThis gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Xie MX, Cao XY, Zeng WA, et al. ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. Nat Commun. 2021,12(1):1401. doi: 10.1038/s41467-021-21731-1Read this paper
- Wu PS, Yen JH, Kou MC, et al. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. PLoS One. 2015,10(6):e0130599. doi: 10.1371/journal.pone.0130599Read this paper
- Lin MH, Yen JH, Weng CY, et al. Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways. Toxicology. 2014,315:24-37. doi: 10.1016/j.tox.2013.11.007Read this paper
- Weng CY, Chiou SY, Wang L, et al. Arsenic trioxide induces unfolded protein response in vascular endothelial cells. Arch Toxicol. 2014,88(2):213-26. doi: 10.1007/s00204-013-1101-xRead this paper





