Overview
- SupplierGeneTex
- Product NameATF4 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.29 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas. Ho KH et al., 2020 Jul, NeurotherapeuticsRead more
- Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP. Chen L et al., 2014 May 8, Cell Death DisRead more
- Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol. Wang TE et al., 2020 Aug 9, Antioxidants (Basel)Read more
- Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. Shih YC et al., 2018 Apr 13, Circ ResRead more
- Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization. Lee TH et al., 2020 Aug 26, Nat CommunRead more
- Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization. Lee TH et al., 2020 Aug 26, Nat CommunRead more
- Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. Oh RS et al., 2012 Feb 17, J Biol ChemRead more
- L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus. Choi YK et al., 2020 May 8, NutrientsRead more
- Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells. Hu LW et al., 2014, PLoS OneRead more
- Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression. Wang IH et al., 2020 Apr 27, Cancers (Basel)Read more