Bio-Connect

ATF4 antibody

GTX101943
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATF4
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATF4 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.7 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID468
  • Target name
    ATF4
  • Target description
    activating transcription factor 4
  • Target synonyms
    CREB-2, CREB2, TAXREB67, TXREB, cyclic AMP-dependent transcription factor ATF-4, DNA-binding protein TAXREB67, cAMP response element-binding protein 2, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, cyclic AMP-responsive element-binding protein 2, tax-responsive enhancer element B67, tax-responsive enhancer element-binding protein 67
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP18848
  • Protein Name
    Cyclic AMP-dependent transcription factor ATF-4
  • Scientific Description
    This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • Krueger ES, Beales JL, Russon KB, et al. Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions. Biomolecules. 2021,11(12). doi: 10.3390/biom11121892
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  • Homma T, Kurahashi T, Ishii N, et al. Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice. Sci Rep. 2020,10(1):17934. doi: 10.1038/s41598-020-74667-9
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  • Lee TH, Yeh CF, Lee YT, et al. Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization. Nat Commun. 2020,11(1):4254. doi: 10.1038/s41467-020-18047-x
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  • Wang TE, Lai YH, Yang KC, et al. Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol. Antioxidants (Basel). 2020,9(8). doi: 10.3390/antiox9080723
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  • Choi YK, Kang JI, Han S, et al. L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus. Nutrients. 2020,12(5). doi: 10.3390/nu12051351
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  • Wang IH, Huang TT, Chen JL, et al. Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression. Cancers (Basel). 2020,12(5). doi: 10.3390/cancers12051088
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  • Ho KH, Chen PH, Chou CM, et al. A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas. Neurotherapeutics. 2020,17(3):1212-1227. doi: 10.1007/s13311-019-00826-0
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  • Virgolini MJ, Feliziani C, Cambiasso MJ, et al. Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside. Biochim Biophys Acta Mol Cell Res. 2019,1866(2):225-239. doi: 10.1016/j.bbamcr.2018.10.014
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