Bio-Connect

ATF4 antibody

GTX101943
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetATF4
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATF4 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.7 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID468
  • Target name
    ATF4
  • Target description
    activating transcription factor 4
  • Target synonyms
    cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB2; CREB-2; cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; TAXREB67; tax-responsive enhancer element B67; tax-responsive enhancer element-binding protein 67; TXREB
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP18848
  • Protein Name
    Cyclic AMP-dependent transcription factor ATF-4
  • Scientific Description
    This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • The Cell Protective Effect of Adenine on Hypoxia-Reoxygenation Injury through PPAR Delta Activation. Leu JG et al., 2021 Dec 16, Life (Basel)
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  • Gut Metabolite Trimethylamine N-Oxide Protects INS-1 beta-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions. Krueger ES et al., 2021 Dec 17, Biomolecules
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  • Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice. Homma T et al., 2020 Oct 21, Sci Rep
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  • Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization. Lee TH et al., 2020 Aug 26, Nat Commun
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  • Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol. Wang TE et al., 2020 Aug 9, Antioxidants (Basel)
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  • L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus. Choi YK et al., 2020 May 8, Nutrients
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  • Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression. Wang IH et al., 2020 Apr 27, Cancers (Basel)
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  • A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas. Ho KH et al., 2020 Jul, Neurotherapeutics
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  • Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside. Virgolini MJ et al., 2019 Feb, Biochim Biophys Acta Mol Cell Res
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