Avapritinib
HY-101561
CAS Number1703793-34-3
Product group Chemicals
Estimated Purity99.94
Molecular Weight498.56
Overview
- SupplierMedChem Express
- Product NameAvapritinib [1703793-34-3]
- Delivery Days Customer10
- CAS Number1703793-34-3
- CertificationResearch Use Only
- Estimated Purity99.94
- Molecular FormulaC26H27FN10
- Molecular Weight498.56
- Scientific DescriptionAvapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC 50 s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V , respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 [1] [2] .
- SMILESCN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200