Avapritinib [1703793-34-3]
T5109
CAS Number1703793-34-3
Product group Chemicals
Estimated Purity99.50%
Molecular Weight498.56
Overview
- SupplierTargetMol Chemicals
- Product NameAvapritinib [1703793-34-3]
- Delivery Days Customer4
- CAS Number1703793-34-3
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameAvapritinib
- Estimated Purity99.50%
- Molecular FormulaC26H27FN10
- Molecular Weight498.56
- Scientific DescriptionAvapritinib (BLU-285) is a selective, highly potent, and orally active inhibitor of KIT and PDGFRA activation loop mutant kinases, targeting KIT D816V (IC50:0.27 nM) and PDGFRA D842V (IC50:0.24 nM), and attenuates the transport functions of ABCB1 and ABCG2. It binds to the active conformation of the kinases and exhibits antitumor activity.
- Shelf life instruction3 years
- SMILESCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
- Storage Instruction-20°C
- UNSPSC12352200
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