Avapritinib (BLU-285)

AbMole BioScience

Avapritinib (BLU-285)

9

1703793-34-3

Chemical

Research Use Only

>99%

C26H27FN10

498.56

Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRalfa D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRalfa D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous KIT mutation, D816V in KIT Exon 17 (IC50 = 0.5 nM).

C[N]1C=C(C=N1)C2=C[N]3N=CN=C(N4CCN(CC4)C5=NC=C(C=N5)C(C)(N)C6=CC=C(F)C=C6)C3=C2

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