beta Arrestin 1 antibody

GeneTex

beta Arrestin 1 antibody

7

WB: 1:500 - 1:2000. ICC/IF: 1:20 - 1:100. IHC-P: 1:50 - 1:200. IP: 1:50 - 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

ARRB1

arrestin beta 1

ARB1; ARR1; arrestin 2; beta-arrestin-1; non-visual arrestin-2

Rabbit

IgG

Beta-arrestin-1

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203