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ProductsBack/beta Catenin (phospho Ser33/Ser37) antibody [BC-22]
The data was published in the journal PLoS Biol in 2018.
The data was published in the journal PLoS Biol in 2018.
The data was published in the journal PLoS Biol in 2018.

beta Catenin (phospho Ser33/Ser37) antibody [BC-22]

GTX11350
GeneTex
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityChicken, Human, Mouse, Rat
TargetCTNNB1
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Overview

  • Supplier
    GeneTex
  • Product Name
    beta Catenin (phospho Ser33/Ser37) antibody [BC-22]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 5-10 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    BC-22
  • Concentration
    2 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1499
  • Target name
    CTNNB1
  • Target description
    catenin beta 1
  • Target synonyms
    CTNNB, EVR7, MRD19, NEDSDV, armadillo, catenin beta-1, catenin (cadherin-associated protein), beta 1, 88kDa
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDP35222
  • Protein Name
    Catenin beta-1
  • Scientific Description
    The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
  • Reactivity
    Chicken, Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chou YT, Jiang JK, Yang MH, et al. Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating β-catenin via a novel C-terminal domain. PLoS Biol. 2018,16(1):e2003714. doi: 10.1371/journal.pbio.2003714
    Read this paper

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