beta Catenin (phospho Ser33/Ser37) antibody [BC-22]

GeneTex

beta Catenin (phospho Ser33/Ser37) antibody [BC-22]

9

The antibody is inhibited more efficiently by the pSer37 peptide than by the pSer33 peptide and is not inhibited by the nonphos-phorylated peptide. It does not detect the unphos-phorylated or the Ser33 phosphorylated protein and does not recognize phospho

WB: 5-10 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA

Research Use Only

Monoclonal

BC-22

2 mg/ml

Unconjugated

Liquid

CTNNB1

catenin beta 1

armadillo; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CTNNB; EVR7; MRD19; NEDSDV

Mouse

IgG2b

Phosphorylated

Catenin beta-1

The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Chicken, Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203