BI-0115

Biorbyt

BI-0115 [4929-23-1]

10

4929-23-1

Research Use Only

C15H14CLN3O

287.74

BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.

ClC1C=C2C(C(=O)N(CCC)C3C(=NC=CC=3)N2)=CC=1

12352200