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BMP4 antibody

GTX100874
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetBMP4
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Overview

  • Supplier
    GeneTex
  • Product Name
    BMP4 antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody is able to recognize full length BMP4 protein (~55kDa) and N-terminal propeptide BMP4 protein (~40kDa) but unable to detect mature form.
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.34 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID652
  • Target name
    BMP4
  • Target description
    bone morphogenetic protein 4
  • Target synonyms
    BMP2B; BMP2B1; bone morphogenetic protein 2B; bone morphogenetic protein 4; MCOPS6; OFC11; ZYME
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP12644
  • Protein Name
    Bone morphogenetic protein 4
  • Scientific Description
    The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5 untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway. An L et al., 2021 Jul, Genes Dis
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  • alphaSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression. McAndrews KM et al., 2021 Jul, Oncogene
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  • Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes. Peng Q et al., 2019 Dec 12, Aging (Albany NY)
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  • TSA restores hair follicle-inductive capacity of skin-derived precursors. Guo L et al., 2019 Feb 27, Sci Rep
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  • Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma. Chiou J et al., 2017 Aug 29, Sci Rep
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