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ProductsBack/Boc-Leu-Arg-Arg-AMC [109358-46-5]
Chemical Structure
Chemical Structure
Chemical Structure

Boc-Leu-Arg-Arg-AMC [109358-46-5]

Research Use Only
AG-CP3-0014
AdipoGen Life Sciences
CAS Number109358-46-5
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight700.8 . 60.1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Boc-Leu-Arg-Arg-AMC
  • Delivery Days Customer
    10
  • CAS Number
    109358-46-5
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C33H52N10O7 . C2H4O2
  • Molecular Weight
    700.8 . 60.1
  • Scientific Description
    Chemical. CAS: 109358-46-5 (free base). Formula: C33H52N10O7 . C2H4O2. MW: 700.8 . 60.1. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues (R and K). Excitation: 380nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis. - Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues (R and K). Excitation: 380nm. Emission: 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
  • SMILES
    Cl.CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(CCCNC(N)=N)C(=O)NC1=CC2=C(C=C1)C(C)=CC(=O)O2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown: A.F. Kisselev, et al.; Mol. Cell 4, 395 (1999)
  • Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits: B.M. Kessler, et al.; Chem. Biol. 8, 913 (2001)
  • Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts: R.E. Morty, et al.; J. Biol. Chem. 280, 10925 (2005)
  • Enzymatic analysis of recombinant Japanese encephalitis virus NS2B(H)-NS3pro protease with fluorogenic model peptide substrates: M. Junaid, et al.; PLoS One 7, e36827 (2012)