BRSK1 Antibody

Cusabio

BRSK1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

BRSK1

BR serine/threonine kinase 1

SAD-B, hSAD1, serine/threonine-protein kinase BRSK1, BR serine/threonine-protein kinase 1, SAD1 homolog, SAD1 kinase, brain-selective kinase 1, brain-specific serine/threonine-protein kinase 1, protein kinase SAD1A, serine/threonine-protein kinase SAD-B, synapses of Amphids Defective homolog 1

Rabbit

IgG

Serine/threonine-protein kinase BRSK1

Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Thr-529 and Ser-579. Also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at Ser-131, leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. Lizcano J.M., EMBO J. 23:833-843(2004). Lu R., J. Biol. Chem. 279:31164-31170(2004). Nagase T., DNA Res. 8:85-95(2001).

Human, Mouse

-20°C or -80°C

41116161